Hydrochlorothiazide in CLDN16 mutation
نویسندگان
چکیده
منابع مشابه
Hydrochlorothiazide in CLDN16 mutation.
BACKGROUND Hydrochlorothiazide (HCT) is applied in the therapy of familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) caused by claudin-16 (CLDN16) mutation. However, the short-term efficacy of HCT to reduce hypercalciuria in FHHNC has not yet been demonstrated in a clinical trial. METHODS Four male and four female patients with FHHNC and CLDN16 mutation, under long-stan...
متن کاملFamilial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): Compound heterozygous mutation in the claudin 16 (CLDN16) gene
BACKGROUND Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive disorder of renal calcium and magnesium wasting frequently complicated by progressive chronic renal failure in childhood or adolescence. METHODS A 7 year old boy was investigated following the findings of marked renal insufficiency and nephrocalcinosis in his 18-month old sister. He ...
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Corresponding author: Nicola Lucio Liberato MD Internal Medicine Ospedale C. Mira Piazzale Volontari del Sangue 27022 Casorate Primo (PV), Italy Phone: +390290040224 Fax: +390290040304 E-mail: lucio_liberato@ ospedali.pavia.it 1 Internal Medicine, Azienda Ospedaliera della Provincia di Pavia, Ospedale Civile “Asilo Vittoria”, Mortara (PV), Italy 2 Internal Medicine, Azienda Ospedaliera della Pr...
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Aqueous solubility and permeability through biomembranes are important parameters for drug bioavailability. Nanoparticles can be considered as a useful tool for improving properties of poorly soluble and/or permeable active ingredients. Hydrochlorothiazide (Class IV of BCS) was chosen as a model compound. Antisolvent precipitation – solvent evaporation and emulsion solvent evaporation methods w...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2006
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfl144